{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

Base Information

Chemical Name:{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol
CAS No.:477231-12-2
Molecular Formula:C₃₂H₃₇NO₂Si
Molecular Weight:495.737
Hs Code.:

{3-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

Synonyms:{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

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Chemical Property of {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

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Technology Process of {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

There total 7 articles about {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 477227-35-3
{3-[4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phenyl}-pyridin-3-yl-methanol

: 477231-12-2
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1016/S0960-894X(02)00005-7

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 477231-12-2
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / nBuLi / tetrahydrofuran / -78 °C

2: 65 percent / H₂ / 10 percent Pd-C / acetic acid; methanol

With n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1016/S0960-894X(02)00005-7

Reference yield:

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 477231-12-2
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: KOtBu / tetrahydrofuran

2: SOCl₂

3: 75 percent / LAH / tetrahydrofuran

4: 100 percent / imidazole / dimethylformamide

5: 62 percent / nBuLi / tetrahydrofuran / -78 °C

6: 65 percent / H₂ / 10 percent Pd-C / acetic acid; methanol

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; 1: Wittig olefination;
DOI:10.1016/S0960-894X(02)00005-7