[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

Base Information

Chemical Name:[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol
CAS No.:915772-52-0
Molecular Formula:C₂₅H₂₈O₃
Molecular Weight:376.496
Hs Code.:

[6-(4-<i>tert</i>-butyl-phenylethynyl)-3-<i>p</i>-tolyloxy-3,6-dihydro-2<i>H</i>-pyran-2-yl]-methanol

Synonyms:[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

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Chemical Property of [6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

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Technology Process of [6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

There total 6 articles about [6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: carbonic acid 6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-ylmethyl ester ethyl ester

: 915772-52-0
[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

Guidance literature:: With potassium carbonate; In methanol; for 3h;
DOI:10.1021/ol0618252

Reference yield:

: 6-(4-tert-butyl-phenylethynyl)-2-hydroxymethyl-3,6-dihydro-2H-pyran-3-ol

: 915772-52-0
[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 222.4 mg / pyridine / CH₂Cl₂ / 15 h / 20 °C

2: (1S,2S)-(-)-1,2-diaminocyclohexane-N,N'-bis(2'-Ph₂P-benzoyl); Pd₂(dba)3*CHCl₃ / CH₂Cl₂ / 0.25 h / 100 °C / microwave irradiation

3: 72 percent / K₂CO₃ / methanol / 3 h

With pyridine; trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; In methanol; dichloromethane;
DOI:10.1021/ol0618252

Reference yield:

: 915772-00-8
acetic acid 2-acetoxymethyl-6-(4-tert-butyl-phenylethynyl)-3,6-dihydro-2H-pyran-3-yl ester

: 915772-52-0
[6-(4-tert-butyl-phenylethynyl)-3-p-tolyloxy-3,6-dihydro-2H-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: macroporous carbonate resin / methanol / 3 h

2: 222.4 mg / pyridine / CH₂Cl₂ / 15 h / 20 °C

3: (1S,2S)-(-)-1,2-diaminocyclohexane-N,N'-bis(2'-Ph₂P-benzoyl); Pd₂(dba)3*CHCl₃ / CH₂Cl₂ / 0.25 h / 100 °C / microwave irradiation

4: 72 percent / K₂CO₃ / methanol / 3 h

With pyridine; trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; macroporous carbonate resin; potassium carbonate; In methanol; dichloromethane;
DOI:10.1021/ol0618252