3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester
CAS No.:1207166-55-9
Molecular Formula:C₆₆H₁₁₃NO₁₀Si₃
Molecular Weight:1164.88
Hs Code.:

3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Synonyms:3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Suppliers and Price of 3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

There total 10 articles about 3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1207166-42-4
14,20-bis(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one

: 149198-47-0
tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate

: 1207166-55-9
3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Guidance literature:: 14,20-bis(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1039/b921237j

Reference yield: 91.0%

: 1207166-42-4
14,20-bis(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one

: C₂₀H₃₁NO₄S

: 1207166-55-9
3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Guidance literature:: 14,20-bis(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11,16-tetraen-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

C₂₀H₃₁NO₄S; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1002/asia.201000541

Reference yield:

: 1082395-55-8
C₄₅H₈₃IO₅Si₂

: 1207166-55-9
3-tert-butoxycarbonylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-10-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) thiophene-2-carboxylate / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

2.1: methanol; potassium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 20 °C

3.2: 0.33 h / 20 °C

4.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 0 - 20 °C

5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 1.17 h / 20 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

6.2: -78 - 0 °C

With methanol; potassium fluoride; copper(I) thiophene-2-carboxylate; 2,4,6-trichlorobenzoyl chloride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; toluene; 1.1: Stille-Liebeskind cross coupling / 3.1: Yamaguchi macrolactonization / 3.2: Yamaguchi macrolactonization;
DOI:10.1002/asia.201000541