1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Base Information

• Chemical Name: 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide
• CAS No.: 69082-44-6
• Molecular Formula: C₂₁H₂₄ClN₃O₄
• Molecular Weight: 417.892

Synonyms:1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Chemical Property of 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Chemical Property:

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Technology Process of 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

There total 3 articles about 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride (69082-74-2) → 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69082-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / H₂ / PtO₂ / ethanol / 6 h / 70 °C / 15514.4 Torr

2: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

3: K₂CO₃ / tetrahydrofuran / 16 h

With sulfuric acid; hydrogen; nitric acid; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1021/jm00366a017

Reference yield:

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide (69082-73-1) → 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69082-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

2: K₂CO₃ / tetrahydrofuran / 16 h

With sulfuric acid; nitric acid; potassium carbonate; In tetrahydrofuran; acetic acid;

DOI:10.1021/jm00366a017

Reference yield:

2-phenylethyl chloride (622-24-2) + N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide (69082-75-3) → 1-Phenethyl-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69082-44-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 16h;

DOI:10.1021/jm00366a017

upstream raw materials:

2-phenylethyl chloride

N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride

Downstream raw materials:

1-Phenethyl-piperidine-4-carboxylic acid (4-amino-5-chloro-2-methoxy-phenyl)-amide

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