Chemical Property of Pizotifen
Chemical Property:
- Vapor Pressure:7.92E-08mmHg at 25°C
- Melting Point:140-142°C
- Boiling Point:436.7°Cat760mmHg
- PKA:pKa 6.95 (Uncertain)
- Flash Point:217.9°C
- PSA：31.48000
- Density:1.164g/cm3
- LogP:4.31210
- Storage Temp.:Refrigerator
- Solubility.:DMSO: ≥8mg/mL
- XLogP3:3.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:295.13947085
- Heavy Atom Count:21
- Complexity:406
- Purity/Quality:
-
99%, *data from raw suppliers
Pizotyline *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,Xn
- Hazard Codes:Xi,Xn
- Statements:
36/37/38-22-63
- Safety Statements:
26-37/39-36/37
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
- Recent EU Clinical Trials:A 12-month prospective, randomized, interventional, global, multi-center, active-controlled study comparing sustained benefit of two treatment paradigms (erenumab qm vs. oral prophylactics) in adult episodic migraine patients
-
Uses
benzocycloheptane based drug Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.
-
Indications
Pizotifen, a potent antihistamine and antiserotonin
agent usually prescribed for migraine prophylaxis, has had reported success
in patients with polycythemia vera.
-
Therapeutic Function
Migraine therapy
-
Clinical Use
Prophylactic treatment of vascular headaches including
migraine
-
Drug interactions
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: pizotifen antagonises
hypotensive effect.
