rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

Base Information

Chemical Name:rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate
CAS No.:1329694-82-7
Molecular Formula:C₁₆H₁₇NO₅
Molecular Weight:303.315
Hs Code.:

Synonyms:rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

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Chemical Property of rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

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Technology Process of rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

There total 3 articles about rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1329694-51-0
rac-2-acryloxy-2-benzyl-1-(2-methoxy-2-oxoethylamino)-1-oxopent-4-ene

: 1329694-82-7
rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

Guidance literature:: With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II); In toluene; at 70 ℃;
DOI:10.1002/ejoc.201100160

Reference yield:

: 140-29-4
phenylacetonitrile

: 1329694-82-7
rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; zinc / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.08 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) / toluene / 70 °C

With aluminum (III) chloride; [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II); zinc; In tetrahydrofuran; dichloromethane; toluene; 1.1: Barbier reaction / 2.1: Passerini reaction / 2.2: Passerini reaction;
DOI:10.1002/ejoc.201100160

Reference yield:

: 82456-37-9
1-phenylpent-4-en-2-one

: 1329694-82-7
rac-methyl 2-(2-benzyl-6-oxo-3,6-dihydro-2H-pyran-2-carboxamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) / toluene / 70 °C

With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II); In dichloromethane; toluene; 1.1: Passerini reaction / 1.2: Passerini reaction;
DOI:10.1002/ejoc.201100160