4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

Base Information

Chemical Name:4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide
CAS No.:1207760-67-5
Molecular Formula:C₂₃H₂₁F₃N₆O₃
Molecular Weight:486.453
Hs Code.:

Synonyms:4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

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Chemical Property of 4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

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Technology Process of 4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

There total 7 articles about 4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852314-00-2
4-chloro-1-(2-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1207831-27-3
2-hydroxy-4-methoxy-N-(5-methylpyridin-2-yl)butanamide

: 1207760-67-5
4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

Guidance literature:: 2-hydroxy-4-methoxy-N-(5-methylpyridin-2-yl)butanamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃;

4-chloro-1-(2-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine; In tetrahydrofuran; at 50 ℃;
DOI:10.1016/j.bmcl.2012.10.090

Reference yield:

: 5266-03-5
2-hydroxy-4-methoxybutanoic acid

: 1207760-67-5
4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

5.2: 50 °C

With pyridine; 1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.090

Reference yield:

: 1415025-16-9
C₁₇H₃₀N₂O₃Si

: 1207760-67-5
4-Methoxy-N-(5-methylpyridin-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

2.2: 50 °C

With tetrabutyl ammonium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.10.090