Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

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Chemical Name:Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester
CAS No.:92803-71-9
Molecular Formula:C₂₁H₃₄O₅S
Molecular Weight:398.564
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

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Chemical Property of Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

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Technology Process of Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

There total 7 articles about Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 92934-88-8
Toluene-4-sulfonic acid (2S,6R)-7-hydroxy-2,6-dimethyl-heptyl ester

: 92803-71-9
Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1139/v84-267

Reference yield:

: 92803-65-1
(S)-2-[(1S,3R)-2,2-Dibromo-3-((R)-2-hydroxy-1-methyl-ethyl)-cyclopropyl]-propan-1-ol

: 92803-71-9
Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / pyridine / toluene; CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) 1.6 M butyllithium / 1.) ether, hexane, -78 deg C, 5 min; 2.) ether, hexane, THF, - 78 deg C, 20 min

3: 97 percent / 1.25 M CH₃Li / diethyl ether / 0.67 h / -35 °C

4: 98 percent / H₂ / 5 percent PtO₂ / methanol / 24 h / Ambient temperature

5: 96 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

6: 76 percent / trichlorosilane / benzene; triethylamine / 24 h / Ambient temperature

7: 94 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; n-butyllithium; trichlorosilane; methyllithium; hydrogen; pyridinium p-toluenesulfonate; triethylamine; platinum(IV) oxide; In methanol; diethyl ether; dichloromethane; triethylamine; toluene; benzene;

Reference yield:

: 92803-68-4
((S)-1-Phenyl-ethyl)-carbamic acid (2R,6S)-7-hydroxy-2,6-dimethyl-hepta-3,4-dienyl ester

: 92803-71-9
Toluene-4-sulfonic acid (2S,6R)-2,6-dimethyl-7-(tetrahydro-pyran-2-yloxy)-heptyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 5 percent PtO₂ / methanol / 24 h / Ambient temperature

2: 96 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

3: 76 percent / trichlorosilane / benzene; triethylamine / 24 h / Ambient temperature

4: 94 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

With trichlorosilane; hydrogen; pyridinium p-toluenesulfonate; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; triethylamine; benzene;