ferrocenyl(2,6-dimethoxyphenyl)methanol

Base Information

• Chemical Name: ferrocenyl(2,6-dimethoxyphenyl)methanol
• CAS No.: 223139-72-8
• Molecular Formula: C₁₉H₂₀FeO₃
• Molecular Weight: 352.213
• Mol file: 223139-72-8.mol

Synonyms:ferrocenyl(2,6-dimethoxyphenyl)methanol

Chemical Property of ferrocenyl(2,6-dimethoxyphenyl)methanol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ferrocenyl(2,6-dimethoxyphenyl)methanol

There total 1 articles about ferrocenyl(2,6-dimethoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ferrocenecarboxaldehyde (12093-10-6) + 1,3-Dimethoxybenzene (151-10-0) → ferrocenyl(2,6-dimethoxyphenyl)methanol (223139-72-8)

Guidance literature:

With BuLi; TMEDA; In diethyl ether; hexane; treatment of arene with BuLi (in hexane) and TMEDA (0°C, Ar-atmosphere), stirring (0°C, 2 h), addn. of FcCHO (in Et2O), stirring (room temp., 24 h); PhMe addn., washing (H2O), concn., hexane addn., crystn. (-30°C);elem. anal.;

DOI:10.1016/S0022-328X(98)00925-5

Reference yield: 97.0%

perchloric acid (7601-90-3) + ferrocenyl(2,6-dimethoxyphenyl)methanol (223139-72-8) → Ferrocenyl(2,6-dimethoxyphenyl)carbenium perchlorate (223139-96-6)

Guidance literature:

In perchloric acid; diethyl ether; aq. HClO4; stirring Fe-complex with slight excess of 60% HClO4 (0°C, 15 min); elem. anal.;

DOI:10.1016/S0022-328X(98)00925-5

Reference yield: 90.0%

ferrocenyl(2,6-dimethoxyphenyl)methanol (223139-72-8) + 1,3-Dimethoxybenzene (151-10-0) → ferrocenyl(2,6-dimethoxyphenyl)(2,4-dimethoxyphenyl)methane (223140-47-4)

Guidance literature:

With trifluoroacetic acid; In further solvent(s); addn. of 1.1 equiv. of CF3COOH to Fe-complex suspn. in 1,3-dimethoxybenzene at 0°C, stirring (0°C, 1 h); filtration (Florisil), addn. of hexane to filtrate, crystn. (-30°C); elem. anal.; can be recrystallized (hexane);

DOI:10.1016/S0022-328X(98)00925-5

upstream raw materials:

ferrocenecarboxaldehyde

1,3-Dimethoxybenzene

Downstream raw materials:

Ferrocenyl(2,6-dimethoxyphenyl)carbenium perchlorate

Ferrocenyl(2,6-dimethoxyphenyl)carbenium tetrafluoroborate

ferrocenyl(2,6-dimethoxyphenyl)(2,4-dimethoxyphenyl)methane

ferrocenyl(2,4,6-trimethoxyphenyl)(2,6-dimethoxyphenyl)methane

Refernces