N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride

Base Information

• Chemical Name: N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride
• CAS No.: 1372180-70-5
• Molecular Formula: C₁₆H₂₂Cl₂N₂O₂*ClH
• Molecular Weight: 381.73
• Mol file: 1372180-70-5.mol

Synonyms:N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride

Chemical Property of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride

There total 5 articles about N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(6R,7R)-tert-butyl 6-(butyramidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride (1372180-70-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2016.05.038

Reference yield:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (1372189-39-3) → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride (1372180-70-5)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide

3: triphenylphosphine / tetrahydrofuran; water / 20 °C

4: triethylamine / tetrahydrofuran / 20 °C

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2016.05.038

Reference yield:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate (1372186-92-9) → N-(((6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl)methyl)butyramide hydrochloride (1372180-70-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide

2: triphenylphosphine / tetrahydrofuran; water / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2016.05.038

upstream raw materials:

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate