Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester
CAS No.:99947-29-2
Molecular Formula:C₁₈H₂₃NO₃S
Molecular Weight:333.452
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Suppliers and Price of Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

There total 2 articles about Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87870-59-5
(-)-2-<2-(cyanomethyl)-2,3-dimethylcyclopent-3-en-1-yl>acetaldehyde

: 99947-29-2
Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 1 h / 25 °C

2: pyridine / 1.) 0 deg C, 5 h, 2.) 25 deg C, 2 h

With sodium tetrahydroborate; In pyridine; methanol;
DOI:10.1021/ja00265a033

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 99947-28-1
[(1S,5S)-5-(2-Hydroxy-ethyl)-1,2-dimethyl-cyclopent-2-enyl]-acetonitrile

: 99947-29-2
Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

Guidance literature:: With pyridine;
DOI:10.1021/ja00252a031

Reference yield:

: 99947-29-2
Toluene-4-sulfonic acid 2-((1S,2S)-2-cyanomethyl-2,3-dimethyl-cyclopent-3-enyl)-ethyl ester

: (3S,4S)-3-Methyl-3-(2-methyl-[1,3]dioxolan-2-yl)-4-(5-phenyl-isoxazol-3-yl)-heptanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: dimethylformamide / 20 °C

2: 1.) O₃, 2.) (CH₃O)3P / 1.) CH₂Cl₂/MeOH, -78 deg C, 2.) 25 deg C, overnight

3: 96.7 percent / NaCNBH₃, sodium acetate / methanol / 24 h / 25 °C

4: 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

5: dimethylsulfoxide; benzene / Heating; the benzene, water, and dimethylhydroxylamine was distilled off

6: 90.6 percent / TsOH / benzene / 20 h / Heating; by azeotropic removal of water

7: NaOH / ethane-1,2-diol; H₂O; methanol / 75 h / 110 °C / the methanol was distilled off

8: ethane-1,2-diol; H₂O; dimethylformamide / 25 °C

9: 1.) O₃, 2.) (CH₃O)3P / 1.) CH₂Cl₂/MeOH, -78 deg C, 1 h, 2.) 25 deg C, overnight

10: 96 percent / HONH₂*HCl / pyridine / 1.) 0 deg C, 1 h, 2.) 25 deg C, overnight

11: 100 percent / N-chlorosuccinimide / dimethylformamide / 1 h / 40 °C / (cooling !)

12: 76 percent / triethylamine / diethyl ether / 0.5 h / 25 °C

13: 70 percent / CH₂Cl₂ / 24 h / 25 °C

With sodium hydroxide; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; sodium cyanoborohydride; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester; toluene-4-sulfonic acid; In pyridine; methanol; diethyl ether; dichloromethane; water; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00265a033