N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Base Information

Chemical Name:N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide
CAS No.:1394808-82-2
Molecular Formula:C₂₁H₃₁N₃O₃
Molecular Weight:373.495
Hs Code.:

Synonyms:N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Suppliers and Price of N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

There total 5 articles about N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110-91-8,99108-56-2
morpholine

: 1394808-81-1
2-chloro-N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]acetamide

: 1394808-82-2
N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Guidance literature:: 2-chloro-N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]acetamide; With potassium carbonate; In acetonitrile; at 25 - 30 ℃; for 0.166667h; Inert atmosphere; Large scale;

morpholine; at 25 - 82 ℃; for 4h; Reflux; Large scale;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1394808-82-2
N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 10 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

4.1: dichloromethane / 1 h / 0 °C

5.1: potassium carbonate / acetonitrile / 5 h / Reflux

With hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 916905-62-9
4-(1-cyclobutylpiperidin-4-yloxy)-1-nitrobenzene

: 1394808-82-2
N-[4-(1-cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

2: dichloromethane / 1 h / 0 °C

3: potassium carbonate / acetonitrile / 5 h / Reflux

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;