2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

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Chemical Name:2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide
CAS No.:1026584-40-6
Molecular Formula:C₁₉H₃₅NOS
Molecular Weight:325.559
Hs Code.:

Synonyms:2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

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Chemical Property of 2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

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Technology Process of 2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

There total 7 articles about 2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2270-59-9
1-bromo-4-methylpent-3-ene

: 2-Methyl-propane-2-sulfinic acid [1-((R)-4-methyl-cyclohex-3-enyl)-eth-(Z)-ylidene]-amide

: 1026584-40-6
2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

Guidance literature:: 1-bromo-4-methylpent-3-ene; With tert.-butyl lithium; In diethyl ether; toluene; pentane; at -78 - 0 ℃;

2-Methyl-propane-2-sulfinic acid [1-((R)-4-methyl-cyclohex-3-enyl)-eth-(Z)-ylidene]-amide; With trimethylaluminum; In toluene; at -78 ℃; for 2h;
DOI:10.1021/ja044753n

Reference yield:

: 2-Methyl-propane-2-sulfinic acid [4-bromo-1-methoxy-but-(E)-ylidene]-amide

: 1026584-40-6
2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 91 percent / NaI / acetone / 20 h / 20 °C

2.1: CuI / tetrahydrofuran / 0.5 h / 20 °C

2.2: 75 percent / tetrahydrofuran / 0.5 h / -48 °C

3.1: 93 percent / NaCN / methanol / 20 h / 50 °C

4.1: KHMDS / toluene; tetrahydrofuran / 1 h / -78 °C

4.2: 82 percent / toluene; tetrahydrofuran / 20 h / -78 °C

5.1: 82 percent / cerium(III) chloride / tetrahydrofuran / 1 h / -48 °C

6.1: 87 percent / Ph-CH=Ru(PCy₃)Cl₂(1,3-MeS₂-imidazolidin-2-yl) / CH₂Cl₂ / 2 h / Heating

7.1: tert-butyllithium / diethyl ether; pentane; toluene / -78 - 0 °C

7.2: 56 percent / Me₃Al / toluene / 2 h / -78 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide; cerium(III) chloride; sodium cyanide; tert.-butyl lithium; potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene; pentane;
DOI:10.1021/ja044753n

Reference yield:

: 2-Methyl-propane-2-sulfinic acid [4-iodo-1-methoxy-but-(E)-ylidene]-amide

: 1026584-40-6
2-Methyl-propane-2-sulfinic acid [(S)-1,5-dimethyl-1-((R)-4-methyl-cyclohex-3-enyl)-hex-4-enyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: CuI / tetrahydrofuran / 0.5 h / 20 °C

1.2: 75 percent / tetrahydrofuran / 0.5 h / -48 °C

2.1: 93 percent / NaCN / methanol / 20 h / 50 °C

3.1: KHMDS / toluene; tetrahydrofuran / 1 h / -78 °C

3.2: 82 percent / toluene; tetrahydrofuran / 20 h / -78 °C

4.1: 82 percent / cerium(III) chloride / tetrahydrofuran / 1 h / -48 °C

5.1: 87 percent / Ph-CH=Ru(PCy₃)Cl₂(1,3-MeS₂-imidazolidin-2-yl) / CH₂Cl₂ / 2 h / Heating

6.1: tert-butyllithium / diethyl ether; pentane; toluene / -78 - 0 °C

6.2: 56 percent / Me₃Al / toluene / 2 h / -78 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide; cerium(III) chloride; sodium cyanide; tert.-butyl lithium; potassium hexamethylsilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1021/ja044753n