(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester
CAS No.:159216-06-5
Molecular Formula:C₄₀H₅₄N₄O₈
Molecular Weight:718.891
Hs Code.:

(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Synonyms:(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Suppliers and Price of (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

There total 49 articles about (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 288404-56-8
2-tert-butoxycarbonylamino-2-[5''-(2-hydroxy-ethyl)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

: 159216-06-5
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1021/ol0059293

Reference yield: 58.0%

: (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5''-(2,3-dihydroxy-3-methyl-butyl)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-2,3,2',3',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

: 159216-06-5
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; for 1h; Ambient temperature;
DOI:10.1021/ja00101a017

Reference yield:

: 145452-11-5
(S)-2-Amino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 159216-06-5
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S,5''S)-5',5''-diisobutyl-2-isopropyl-3,4',4''-trioxo-5''-(2-oxo-ethyl)-2,3,4',5',4'',5''-hexahydro-1H,1'H,1''H-[2,3';5',3'']terpyrrol-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: i-Pr₂NEt / tetrahydrofuran / 4 h / 20 °C

2: O₃; Ph₃P / CH₂Cl₂ / -78 °C

3: 80 percent / NaBH₃CN; aq. HCl / methanol / 3 h / 20 °C

4: 84 percent / H₂ / Pd(C) / ethanol / 1 h

5: (MeO)3CH / tetrahydrofuran / 14 h / 20 °C

6: 77 percent / KHMDS; 18-crown-6 / tetrahydrofuran; toluene / 4 h / 20 °C

7: 80 percent / (COCl)2; DMSO; DBU / CH₂Cl₂ / 0.33 h / 20 °C

8: (MeO)3CH / tetrahydrofuran

9: KHMDS; 18-crown-6

10: 65 percent / (COCl)2; DMSO; DBU / CH₂Cl₂ / 0.33 h / 20 °C

With hydrogenchloride; oxalyl dichloride; 18-crown-6 ether; hydrogen; potassium hexamethylsilazane; sodium cyanoborohydride; ozone; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethyl orthoformate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 1: benzyloxycarbonylation / 2: Oxidation / 3: Reduction / 4: Hydrogenation / 5: Condensation / 6: Cyclization / 7: Swern oxidation / 8: Condensation / 9: Cyclization / 10: Swern oxidation;
DOI:10.1021/ol0059293