12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

Base Information

Chemical Name:12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine
CAS No.:1393589-78-0
Molecular Formula:C₂₆H₃₃NO
Molecular Weight:375.554
Hs Code.:

Synonyms:12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

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Chemical Property of 12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

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Technology Process of 12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

There total 6 articles about 12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1393589-77-9
N-benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hex-5-enyl)oxy)benzyl)hex-5-en-1-amine

: 1393589-78-0
12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; chloroacetone; In methanol; water; Inert atmosphere;
DOI:10.1021/ol3020623

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 1393589-78-0
12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / Inert atmosphere; Reflux

3.1: sodium triacetoxyborohydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 16 h / 0 - 20 °C / Inert atmosphere

5.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; chloroacetone / methanol; water / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sodium triacetoxyborohydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; chloroacetone; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol3020623

Reference yield:

: 76911-01-8
5-hexynyl p-toluenesulfonate

: 1393589-78-0
12-benzyl-6,7-dimethylene-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo-[b][1,5]oxaazacyclopentadecine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / Inert atmosphere; Reflux

2.1: sodium triacetoxyborohydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 16 h / 0 - 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; chloroacetone / methanol; water / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sodium triacetoxyborohydride; diisobutylaluminium hydride; potassium carbonate; chloroacetone; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol3020623