(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

Base Information

Chemical Name:(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide
CAS No.:252192-75-9
Molecular Formula:C₂₂H₂₉NO₄S₂
Molecular Weight:435.609
Hs Code.:

Synonyms:(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

Chemical Property:

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Technology Process of (3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

There total 4 articles about (3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105850-89-3
chloromethyl (trimethylsilyl)methyl sulfide

: 252192-73-7
N-((E)-3-benzyloxypropenoyl)-(1S)-camphorsultam

: (3S,4R)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

: 252192-75-9
(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

Guidance literature:: With cesium fluoride; In acetonitrile; at 0 ℃;
DOI:10.1016/j.tetlet.2007.05.080

Reference yield:

: 105850-89-3
chloromethyl (trimethylsilyl)methyl sulfide

: 252192-73-7
N-((E)-3-benzyloxypropenoyl)-(1S)-camphorsultam

: 252192-75-9
(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

Guidance literature:: With cesium fluoride; In acetonitrile; at 0 ℃; for 192h;
DOI:10.1016/j.tetlet.2007.08.123

Reference yield:

: 154581-21-2
(E)-3-benzyloxypropenoyl chloride

: 252192-75-9
(3R,4S)-4-benzyloxy-tetrahydrothiophene-3-carboxylic (1S)-camphorsultam amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: MeMgBr / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

1.2: 82 percent / tetrahydrofuran; diethyl ether / 1 h / 0 °C

2.1: CsF / acetonitrile / 72 h / 0 °C

With methylmagnesium bromide; cesium fluoride; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/ol9910565