2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

Base Information

Chemical Name:2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid
CAS No.:1422175-56-1
Molecular Formula:C₁₈H₁₀ClF₄N₃O₃
Molecular Weight:427.742
Hs Code.:

Synonyms:2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

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Chemical Property of 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

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Technology Process of 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

There total 8 articles about 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422175-55-0
methyl 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]amino}benzoate

: 1422175-56-1
2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

Guidance literature:: methyl 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]amino}benzoate; With water; lithium hydroxide; for 2h;

With acetic acid;

Reference yield:

: 7292-73-1
(2RS)-N-(p-fluorophenyl)glycine

: 1422175-56-1
2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 20 °C

2.1: tributylphosphine / toluene / 12 h / 20 °C

3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 2585.81 Torr

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

4.2: 48 h / Reflux

5.1: water; lithium hydroxide / 2 h

With tributylphosphine; 5%-palladium/activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In ethanol; dichloromethane; toluene;

Reference yield:

: 6307-82-0
2-chloro-5-nitro-benzoic acid methyl ester

: 1422175-56-1
2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]-amino}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate; ethanol / 2 h / Sealed tube; Sonication

2.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

2.2: 48 h / Reflux

3.1: water; lithium hydroxide / 2 h

With tin(II) chloride dihdyrate; ethanol; water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In dichloromethane;