trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester

Base Information

• Chemical Name: trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester
• CAS No.: 882041-77-2
• Molecular Formula: C₂₁H₂₂F₆O₆S₂
• Molecular Weight: 548.524
• Mol file: 882041-77-2.mol

Synonyms:trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester

Chemical Property of trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester

There total 1 articles about trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3,3-bis[4-hydroxy-3-methylphenyl]pentane (55041-27-5) → trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester (882041-77-2)

Guidance literature:

With triethylamine; In dichloromethane; for 2h;

DOI:10.1016/j.bmcl.2005.06.044

Reference yield: 54.0%

trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester (882041-77-2) + benzylamine (100-46-9) → C33H38N2 (882041-88-5)

Guidance literature:

With palladium diacetate; caesium carbonate; johnphos; In toluene; at 100 ℃; for 14h;

DOI:10.1016/j.bmcl.2005.06.044

Reference yield:

trifluoro-methanesulfonic acid 4-[1-ethyl-1-(3-methyl-4-trifluoromethanesulfonyloxy-phenyl)-propyl]-2-methyl-phenyl ester (882041-77-2) → DPP-1111 (863408-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / Pd(OAc)2; 2-(di-tert-butylphosphino)biphenyl; Cs₂CO₃ / toluene / 14 h / 100 °C

2: 95 percent / H₂ / Pd(OH)2/C / dimethylformamide / 16 h

3: 59 percent / KI; Et₃N / dimethylformamide / 24 h

With palladium diacetate; hydrogen; caesium carbonate; triethylamine; potassium iodide; johnphos; palladium dihydroxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2005.06.044

upstream raw materials:

trifluoromethylsulfonic anhydride

3,3-bis[4-hydroxy-3-methylphenyl]pentane

Downstream raw materials:

C₃₃H₃₈N₂

3,3-bis(4-amino-3-methylphenyl)pentane

DPP-1111