3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine

Base Information

• Chemical Name: 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine
• CAS No.: 220867-50-5
• Molecular Formula: C₂₆H₂₆N₆O₉S
• Molecular Weight: 598.593

Synonyms:3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine

Chemical Property of 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine

Chemical Property:

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Technology Process of 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine

There total 1 articles about 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

p-toluenesulfonyl chloride (98-59-9) + 3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112237-60-2) → 3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine (220867-50-5)

Guidance literature:

With pyridine; for 18h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

Reference yield: 86.0%

3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine (220867-50-5) → 5-azido-3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (220867-51-6)

Guidance literature:

With lithium azide; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

Reference yield:

3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-O-<(p-toluyl)sulfonyl>adenosine (220867-50-5) → 5'amino-3',5'-dideoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (220867-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / LiN₃ / dimethylformamide / 2 h / 65 °C

2: 96 percent / Ph₃P / dioxane / 24 h / Ambient temperature

With lithium azide; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1522-2675(19990113)82:1<19::AID-HLCA19>3.0.CO;2-G

upstream raw materials:

p-toluenesulfonyl chloride

3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Downstream raw materials:

5-azido-3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

5'amino-3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine

3',5'-dideoxy-5'-(hexadecanoylamino)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

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