(2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid

Base Information

• Chemical Name: (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid
• CAS No.: 108395-26-2
• Molecular Formula: C₂₀H₂₅NO₄S
• Molecular Weight: 375.489
• Mol file: 108395-26-2.mol

Synonyms:(2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid

Chemical Property of (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid

There total 6 articles about (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid (80828-13-3,80875-98-5,82717-40-6,87679-20-7,87679-39-8,87679-51-4,87679-58-1,88547-85-7,88585-94-8,96844-78-9,108507-42-2,145438-94-4,145438-95-5,145513-90-2,145513-91-3,145513-92-4,145513-93-5,2055118-14-2) → (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid (108395-26-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 96.6 percent / 2N NaOH / H₂O / 3 h / 5 °C

3: 87.8 percent / HCl / H₂O / 4 h / Heating

4: 1.) hexamethyldisilazane, chlorotrimethylsilane / 1.) CH₃CN, reflux, 3 h, 2.) CH₃CN, a) 0 deg C, 1 h, b) from 0 deg C to reflux

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; In water;

DOI:10.1021/jm00389a006

Reference yield:

2-carbethoxyindole (3770-50-1,117770-52-2) → (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid (108395-26-2)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂ / Rh/C / acetic acid

2: aq. 15percent HCl / 4 h / Heating

3: 96.6 percent / 2N NaOH / H₂O / 3 h / 5 °C

5: 87.8 percent / HCl / H₂O / 4 h / Heating

6: 1.) hexamethyldisilazane, chlorotrimethylsilane / 1.) CH₃CN, reflux, 3 h, 2.) CH₃CN, a) 0 deg C, 1 h, b) from 0 deg C to reflux

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; hydrogen; 1,1,1,3,3,3-hexamethyl-disilazane; Rh on carbon; In water; acetic acid;

DOI:10.1021/jm00389a006

Reference yield:

(2S,3aS,7aS)-1-Benzoyl-octahydro-indole-2-carboxylic acid (80875-99-6) → (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid (108395-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87.8 percent / HCl / H₂O / 4 h / Heating

2: 1.) hexamethyldisilazane, chlorotrimethylsilane / 1.) CH₃CN, reflux, 3 h, 2.) CH₃CN, a) 0 deg C, 1 h, b) from 0 deg C to reflux

With hydrogenchloride; chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; In water;

DOI:10.1021/jm00389a006

upstream raw materials:

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S)-3-benzoylthio-2-methylpropionyl chloride

2-carbethoxyindole

(+/-)-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid