2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester

Base Information

• Chemical Name: 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester
• CAS No.: 307335-43-9
• Molecular Formula: C₂₅H₃₀ClN₃O₆
• Molecular Weight: 503.983

Synonyms:2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester

Chemical Property of 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester

There total 2 articles about 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-nitrobenzyl chloride (612-23-7) + 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester (307335-41-7) → 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester (307335-43-9)

Guidance literature:

With sodium ethanolate; In ethanol; for 15h; Heating;

DOI:10.1016/S0960-894X(00)00421-2

Reference yield:

Diethyl 2-bromomalonate (685-87-0) → 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester (307335-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃ / acetonitrile / 18 h / 20 °C

2: 54 percent / NaOEt / ethanol / 15 h / Heating

With sodium ethanolate; potassium carbonate; In ethanol; acetonitrile; 1: Alkylation / 2: Alkylation;

DOI:10.1016/S0960-894X(00)00421-2

Reference yield: 91.0%

2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester (307335-43-9) → 2-(2-amino-benzyl)-2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester (307335-44-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1016/S0960-894X(00)00421-2

upstream raw materials:

2-nitrobenzyl chloride

2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester

Diethyl 2-bromomalonate

Downstream raw materials:

2-(2-amino-benzyl)-2-[4-(4-chloro-benzyl)-piperazin-1-yl]-malonic acid diethyl ester

3-[4-(4-chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one

3-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 307335-43-9 2-[4-(4-chloro-benzyl)-piperazin-1-yl]-2-(2-nitro-benzyl)-malonic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send