5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

Base Information

Chemical Name:5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one
CAS No.:109742-18-9
Molecular Formula:C₂₇H₄₆N₂O₄Si
Molecular Weight:490.759
Hs Code.:

Synonyms:5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

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Chemical Property of 5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

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Technology Process of 5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

There total 14 articles about 5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 109742-11-2
4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

: 501-53-1,94274-21-2
benzyl chloroformate

: 109742-18-9
5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

Guidance literature:: With sodium hydroxide; In chloroform; water; for 2.5h;

Reference yield:

: 109742-04-3
4-(2-oxoheptyl)azetidin-2-one

: 109742-18-9
5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / NaBH₄ / methanol / 1 h / 0 °C

2: 1.) BuLi, 2.) BuLi, copper(I) iodide / 1.) THF, hexane, 0 deg C to RT, 6 h, 2.) THF, hexane, 0 deg C to RT, 16 h

3: 77 percent / KOH / tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 84 h / Ambient temperature

4: 79 percent / NH₃ liq. / 312 h

5: 79 percent / NaOH / CHCl₃; H₂O / 2.5 h

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; ammonia; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; chloroform; water;

Reference yield:

: 109742-06-5
4-(2-hydroxyheptyl)azetidin-2-one

: 109742-18-9
5-benzyloxocarbonyl-4-<2-(tert-butyldimethylsiloxy)heptyl>-1,5-diazacyclooctan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi, 2.) BuLi, copper(I) iodide / 1.) THF, hexane, 0 deg C to RT, 6 h, 2.) THF, hexane, 0 deg C to RT, 16 h

2: 77 percent / KOH / tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 84 h / Ambient temperature

3: 79 percent / NH₃ liq. / 312 h

4: 79 percent / NaOH / CHCl₃; H₂O / 2.5 h

With potassium hydroxide; sodium hydroxide; copper(l) iodide; n-butyllithium; ammonia; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; chloroform; water;