3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

Base Information

Chemical Name:3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide
CAS No.:1092393-72-0
Molecular Formula:C₂₅H₂₂N₆O₄
Molecular Weight:470.487
Hs Code.:

Synonyms:3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

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Chemical Property of 3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

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Technology Process of 3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

There total 7 articles about 3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1092395-06-6
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

: 13831-31-7
Acetoxyacetyl chloride

: 1092393-72-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

Guidance literature:: N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide; Acetoxyacetyl chloride; With pyridine; at 20 ℃; for 18h;

With methanol; water; potassium carbonate; at 20 ℃; for 19h;

Reference yield:

: 1092395-14-6
3-(1-cyanocyclopropyl)benzoyl chloride

: 1092393-72-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 43.5 h / 20 - 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 2280.15 Torr

4.1: dimethyl sulfoxide / 21 h / 20 °C

5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 3 h / 60 °C

6.1: pyridine / 18 h / 20 °C

6.2: 19 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1092395-04-4
3-(1-cyano-1-methylethyl)-N-(3-hydroxyphenyl)benzamide

: 1092393-72-0
3-(1-cyano-1-methylethyl)-N-[3-({2-[(hydroxyacetyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 43.5 h / 20 - 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C / 2280.15 Torr

3.1: dimethyl sulfoxide / 21 h / 20 °C

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 3 h / 60 °C

5.1: pyridine / 18 h / 20 °C

5.2: 19 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;