methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

Base Information

Chemical Name:methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate
CAS No.:1087353-83-0
Molecular Formula:C₁₂H₁₄FN₃O₄
Molecular Weight:283.259
Hs Code.:

Synonyms:methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

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Chemical Property of methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

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Technology Process of methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

There total 3 articles about methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1087353-82-9
benzyl-[5-(aminomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-phenyl]-carbamate

: 1087353-83-0
methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 8h;

Reference yield:

: 219664-23-0
benzyl 4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenylbenzylcarbamate

: 1087353-83-0
methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / chloroform / 0.5 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 8 h

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; chloroform;

Reference yield:

: 851529-79-8
benzyl-[4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-phenyl]-carbamate

: 1087353-83-0
methyl [3-(4-amino-3-fluoro-phenyl)-2-oxo-oxazolidin-5-yl-methyl]-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 4 h

1.2: 16 h / 40 - 50 °C

2.1: triethylamine / chloroform / 0.5 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h

With hydrogen; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform;