ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
• CAS No.: 107752-88-5
• Molecular Formula: C₁₈H₁₈ClNO₄
• Molecular Weight: 347.798
• Mol file: 107752-88-5.mol

Synonyms:ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Chemical Property of ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Chemical Property:

• Melting Point: 183-184 °C(Solv: ethanol (64-17-5))
• Boiling Point: 540.8±50.0 °C(Predicted)
• PKA: 3.48±0.40(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

There total 5 articles about ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorobenzaldehyde (104-88-1) + 1,3-cylohexanedione (504-02-9) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate (107752-88-5)

Guidance literature:

With C₉H₁₈N₂O₃PolSi⁽¹⁺⁾*Cl^(1-); In ethanol; water; for 2h; Reflux;

DOI:10.1016/j.apcata.2011.04.012

Reference yield: 84.0%

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate (2169-68-8) + 1,3-cylohexanedione (504-02-9) → ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate (107752-88-5)

Guidance literature:

With morpholine; In ethanol; Heating;

Reference yield:

4-chlorobenzaldehyde (104-88-1) → ethyl 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate (107752-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride monohydrate / 2 h / 60 °C

2: ethylene glycol / 4 h / 80 °C

With potassium fluoride monohydrate; In ethylene glycol;

DOI:10.1002/jhet.2183

upstream raw materials:

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate

1,3-cylohexanedione

4-chlorobenzaldehyde

ethyl 2-cyanoacetate

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