4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

Base Information

Chemical Name:4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester
CAS No.:1203597-28-7
Molecular Formula:C₂₅H₂₇F₂N₃O₄
Molecular Weight:471.504
Hs Code.:

Synonyms:4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

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Chemical Property of 4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

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Technology Process of 4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

There total 1 articles about 4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1203598-47-3
4-bromo-1-difluoromethoxy-2-ethoxy-benzene

: 1203598-48-4
4-[(pyrimidin-5-ylmethyl)-amino]-benzoic acid tert-butyl ester

: 1203597-28-7
4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,2-dimethoxyethane; toluene; at 20 - 60 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1203597-28-7
4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester

: 1203593-63-8
4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid

Guidance literature:: 4-[(4-difluoromethoxy-3-ethoxyphenyl)pyrimidin-5-ylmethyl-amino]benzoic acid tert-butyl ester; With potassium hydroxide; In ethanol; for 4h; Reflux;

With hydrogenchloride; In water; toluene; at 70 ℃; pH=6.5;