8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine

Base Information

• Chemical Name: 8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine
• CAS No.: 1569695-90-4
• Molecular Formula: C₂₃H₄₂O₂Si₄
• Molecular Weight: 462.927
• Mol file: 1569695-90-4.mol

Synonyms:8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine

Chemical Property of 8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine

There total 1 articles about 8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-hexa-3,5-dien-1-ol (73670-87-8) → 8-methyl-1,1-bis(trimethylsilyl)-11b-(trimethylsilyloxy)-1,2,4a,5,6,11b-hexahydrobenzo[b]silino[2,3-d]oxepine (1569695-90-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication

2.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4.2: 3 h / -78 °C / Inert atmosphere

5.1: toluene / 1.5 h / 180 °C / Inert atmosphere

With oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 1.1: |Mitsunobu Displacement / 5.1: |Diels-Alder Cycloaddition;

DOI:10.1039/c3cc49526d

upstream raw materials:

(E)-hexa-3,5-dien-1-ol