2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Base Information

Chemical Name:2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one
CAS No.:1221486-14-1
Molecular Formula:C₂₂H₁₈ClNO₂
Molecular Weight:363.843
Hs Code.:

Synonyms:2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

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Chemical Property of 2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

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Technology Process of 2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

There total 6 articles about 2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1221486-46-9
2-chloro-7-methoxy-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one

: 95-51-2
o-chloroaniline

: 1221486-14-1
2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: With palladium diacetate; sodium t-butanolate; XPhos; In toluene; tert-butyl alcohol; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300327h

Reference yield:

: 1353948-58-9
2-(3-chlorophenethenyl)-5-methoxy-benzoic acid

: 1221486-14-1
2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

2.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

With thionyl chloride; palladium on activated charcoal; hydrogen; palladium diacetate; sodium t-butanolate; XPhos; In dichloromethane; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 2.2: Friedel Crafts reaction / 3.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h

Reference yield:

: 4785-56-2
2-formyl-5-methoxy-benzoic acid

: 1221486-14-1
2-(2-chlorophenylamino)-7-methoxy-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / methanol / 2 h / Reflux

1.2: 3.75 h / 0 °C

2.1: palladium on activated charcoal; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

3.2: 1.5 h / 20 °C

4.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

With thionyl chloride; palladium on activated charcoal; hydrogen; palladium diacetate; triphenylphosphine; sodium t-butanolate; XPhos; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 1.2: Wittig reaction / 3.2: Friedel Crafts reaction / 4.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h