(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

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Chemical Name:(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester
CAS No.:333363-53-4
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

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Chemical Property of (R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

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Technology Process of (R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

There total 10 articles about (R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 127-17-3
2-oxo-propionic acid

: (R)-4-Methyl-2-(methyl-(S)-1-pyrrolidin-2-ylmethyl-amino)-pentanoic acid benzyl ester; hydrochloride

: 333363-53-4
(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane;
DOI:10.1016/S0960-894X(00)00638-7

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 333363-53-4
(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Et₃N / CH₂Cl₂

2: 85 percent / NaBH₄; LiCl; EtOH / tetrahydrofuran

3: 81 percent / SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂

4: 88 percent / Na(AcO)3BH; AcOH / CH₂Cl₂

5: 90 percent / HCl / dioxane

6: 70 percent / BOP; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; pyridine-SO₃ complex; ethanol; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0960-894X(00)00638-7

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 333363-53-4
(R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂

2: 88 percent / Na(AcO)3BH; AcOH / CH₂Cl₂

3: 90 percent / HCl / dioxane

4: 70 percent / BOP; NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; pyridine-SO₃ complex; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/S0960-894X(00)00638-7