2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Base Information

Chemical Name:2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite
CAS No.:1219089-76-5
Molecular Formula:C₄₆H₅₂N₅O₉PS
Molecular Weight:881.987
Hs Code.:

Synonyms:2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Suppliers and Price of 2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

There total 5 articles about 2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₃₅N₃O₈S

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1219089-76-5
2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Guidance literature:: With 4-methyl-morpholine; 1-methyl-1H-imidazole; In tetrahydrofuran;

Reference yield:

: 1082068-98-1
2'-O-phenylamine-carbothioate uridine

: 1219089-76-5
2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine / dichloromethane / 0.5 h

2: 4-methyl-morpholine / dichloromethane

With 4-methyl-morpholine; In dichloromethane;
DOI:10.1021/ja201561z

Reference yield:

: 165589-89-9
5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine

: 1219089-76-5
2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; hydrogen fluoride / 2-methyltetrahydrofuran / 2 h / 0 - 20 °C

2: 4-methyl-morpholine / dichloromethane / 0.5 h

3: 4-methyl-morpholine / dichloromethane

With 4-methyl-morpholine; pyridine; hydrogen fluoride; In 2-methyltetrahydrofuran; dichloromethane;
DOI:10.1021/ja201561z