N-alpha-benzoyl-(epsilon-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))lysyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide

Base Information

• Chemical Name: N-alpha-benzoyl-(epsilon-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))lysyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide
• CAS No.: 157610-41-8
• Molecular Formula: C₅₈H₆₉N₁₃O₁₁
• Molecular Weight: 1124.27
• Mol file: 157610-41-8.mol

Synonyms:2,1,3-Benzoxadiazole,L-norleucinamide deriv.

Chemical Property of N-alpha-benzoyl-(epsilon-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))lysyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 13.25±0.46(Predicted)
• Flash Point: °C
• Density: 1.348g/cm³

Purity/Quality:

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Technology Process of N-alpha-benzoyl-(epsilon-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))lysyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide

There total 5 articles about N-alpha-benzoyl-(epsilon-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))lysyl-alanyl-tryptophyl-phenylalanyl-prolyl-prolyl-norleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-fluoro-7-nitro-2,1,3-benzoxadiazole (29270-56-2) + PhCO-Lys-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 (157610-40-7) → PhCO-Lys(ε-NBD)-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 (157610-41-8)

Guidance literature:

With sodium borate; In N,N-dimethyl-formamide; at 4 ℃; for 1.5h;

DOI:10.1021/jm00039a012

Reference yield:

Fmoc-Pro-OH (71989-31-6) → PhCO-Lys(ε-NBD)-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 (157610-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Fmoc-4-methoxy-4'-<(γ-carboxypropyl)oxy>benzhydrylamine alanyl aminomethyl polystyrene

2: 73 percent / aq. sodium borate / dimethylformamide / 1.5 h / 4 °C

With sodium borate; Fmoc-4-methoxy-4'-<(γ-carboxypropyl)oxy>benzhydrylamine alanyl aminomethyl polystyrene; In N,N-dimethyl-formamide;

DOI:10.1021/jm00039a012

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → PhCO-Lys(ε-NBD)-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2 (157610-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Fmoc-4-methoxy-4'-<(γ-carboxypropyl)oxy>benzhydrylamine alanyl aminomethyl polystyrene

2: 73 percent / aq. sodium borate / dimethylformamide / 1.5 h / 4 °C

With sodium borate; Fmoc-4-methoxy-4'-<(γ-carboxypropyl)oxy>benzhydrylamine alanyl aminomethyl polystyrene; In N,N-dimethyl-formamide;

DOI:10.1021/jm00039a012

upstream raw materials:

4-fluoro-7-nitro-2,1,3-benzoxadiazole

PhCO-Lys-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH₂

Fmoc-Pro-OH

Fmoc-Lys(tert-butoxycarbonyl)

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