3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 1227831-42-6
• Molecular Formula: C₂₅H₂₄N₄O₂
• Molecular Weight: 412.491

Synonyms:3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

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Technology Process of 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one

There total 5 articles about 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-[4-(3-(4-methoxyphenyl)acryloyl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one (1227831-34-6) → 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one (1227831-42-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 12h; Reflux;

DOI:10.1002/ardp.200900220

Reference yield:

N-(4-acetylphynyl)-2-(methylamino)benzamide (348612-62-4) → 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one (1227831-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / ethanol; water / Reflux

2: sodium hydroxide / methanol; water / 48 h / 20 °C

3: hydrazine hydrate / ethanol / 12 h / Reflux

With hydrazine hydrate; acetic acid; sodium hydroxide; In methanol; ethanol; water; 1: Mannich reaction / 2: Claisen-Schmidt alkaline condensation;

DOI:10.1002/ardp.200900220

Reference yield:

N-Methylisatoic anhydride (10328-92-4) → 3-[4-(5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one (1227831-42-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / Reflux

2: acetic acid / ethanol; water / Reflux

3: sodium hydroxide / methanol; water / 48 h / 20 °C

4: hydrazine hydrate / ethanol / 12 h / Reflux

With hydrazine hydrate; acetic acid; sodium hydroxide; In methanol; ethanol; water; 2: Mannich reaction / 3: Claisen-Schmidt alkaline condensation;

DOI:10.1002/ardp.200900220

upstream raw materials:

3-[4-(3-(4-methoxyphenyl)acryloyl)phenyl]-1-methyl-2,3-dihydroquinazolin-4(1H)-one

N-(4-acetylphynyl)-2-(methylamino)benzamide

3-(4-acetylphenyl)-1-methyl-2,3-dihydroquinazolin-4(1H)-one

N-Methylisatoic anhydride

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