(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

Base Information

Chemical Name:(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid
CAS No.:1069046-82-7
Molecular Formula:C₂₅H₁₈FNO₃
Molecular Weight:399.421
Hs Code.:

Synonyms:(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

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Chemical Property of (2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

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Technology Process of (2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

There total 6 articles about (2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1069042-83-6
methyl (2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoate

: 1069046-82-7
(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

Guidance literature:: methyl (2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoate; With sodium hydroxide; In tetrahydrofuran; methanol; water; Heating;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;
DOI:10.1021/jm500494y

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1069046-82-7
(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) bromide; potassium carbonate; potassium hydroxide; copper diacetate / 140 °C

2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube

3.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

3.2: 3 h / 20 °C

4.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating

4.2: pH 1

With aluminum (III) chloride; copper diacetate; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; copper(I) bromide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: |Heck Reaction / 3.1: |Friedel-Crafts Acylation / 3.2: |Friedel-Crafts Acylation;
DOI:10.1021/jm500494y

Reference yield:

: 504424-70-8
5-bromo-1-phenyl-1H-indole

: 1069046-82-7
(2E)-3-{3-[(4-fluorophenyl)acetyl]-1-phenyl-1H-indol-5-yl}-2-propenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube

2.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

2.2: 3 h / 20 °C

3.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating

3.2: pH 1

With aluminum (III) chloride; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: |Heck Reaction / 2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation;
DOI:10.1021/jm500494y