4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

Base Information

Chemical Name:4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate
CAS No.:1312472-58-4
Molecular Formula:C₇H₈O₃S*C₁₀H₁₇N
Molecular Weight:323.456
Hs Code.:

Synonyms:4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

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Chemical Property of 4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

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Technology Process of 4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

There total 9 articles about 4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1312472-36-8
4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepine

: 104-15-4
toluene-4-sulfonic acid

: 1312472-58-4
4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

Guidance literature:: In dichloromethane; water;
DOI:10.1021/ol201448h

Reference yield:

: 1312472-81-3
tert-butyl (5-((dimethylamino)methyl)-6-(methoxy(methyl)amino)-3,3-dimethyl-6-oxohexyl)carbamate

: 1312472-58-4
4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 0.75 h / Inert atmosphere; Reflux

4.1: potassium hydroxide / dichloromethane; water

5.1: dichloromethane; water

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/ol201448h

Reference yield:

: 1312472-80-2
tert-butyl 3-((dimethylamino)methyl)-5,5-dimethyl-2-oxoazepane-1-carboxylate

: 1312472-58-4
4,4,7-trimethyl-6-methylene-3,4,5,6-tetrahydro-2H-azepin-1-ium 4-toluenesolfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trimethylaluminum / dichloromethane; toluene / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 0.75 h / Inert atmosphere; Reflux

5.1: potassium hydroxide / dichloromethane; water

6.1: dichloromethane; water

With trimethylaluminum; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/ol201448h