2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide

Base Information

• Chemical Name: 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide
• CAS No.: 946088-46-6
• Molecular Formula: C₃₂H₃₈N₄O₃
• Molecular Weight: 526.679

Synonyms:2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide

Chemical Property of 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide

Chemical Property:

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Technology Process of 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide

There total 2 articles about 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

5-allyl-6-methyl-2-phenyl-pyrimidin-4-ol (255869-27-3) + 2-(3,4-dimethoxyphenyl)ethyl isocyanide (63609-01-8) + 1-amino-2-propene (107-11-9,30551-89-4) + Cyclopropanecarboxaldehyde (1489-69-6) → 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide (946088-46-6)

Guidance literature:

In toluene; at 110 ℃; for 120h;

DOI:10.1021/jo070706c

Reference yield:

2-acetyl-pent-4-enoic acid ethyl ester (610-89-9,84984-48-5) → 2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide (946088-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / NaOEt / ethanol / 80 °C

2: 69 percent / toluene / 120 h / 110 °C

With sodium ethanolate; In ethanol; toluene;

DOI:10.1021/jo070706c

Reference yield: 89.0%

2-[(allyl)(5-allyl-6-methyl-2-phenyl-pyrimidin-4-yl)amino]-2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]acetamide (946088-46-6) → 2-cyclopropyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-(4-methyl-2-phenyl-7,8-dihydropyrimido[4,5-b]azepin-9-yl)-acetamide

Guidance literature:

Hoveyda-Grubbs catalyst second generation; In toluene; at 110 ℃; for 24h;

DOI:10.1021/jo070706c

upstream raw materials:

5-allyl-6-methyl-2-phenyl-pyrimidin-4-ol

2-(3,4-dimethoxyphenyl)ethyl isocyanide

1-amino-2-propene

Cyclopropanecarboxaldehyde

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