2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

Base Information

Chemical Name:2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid
CAS No.:1422361-70-3
Molecular Formula:C₁₈H₁₇Cl₂F₂N₃O₅
Molecular Weight:464.253
Hs Code.:

Synonyms:2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

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Chemical Property of 2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

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Technology Process of 2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

There total 7 articles about 2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1422361-70-3
2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

Guidance literature:: With lithium hydroxide; In methanol; at 60 ℃; for 1.33333h;

With hydrogenchloride; In methanol; water; pH=4;

Reference yield:

: 1422361-83-8
3-(3-bromopropoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

: 1422361-70-3
2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 1.5 h / Reflux

2: lithium hydroxide

With potassium carbonate; lithium hydroxide; In acetonitrile;
DOI:10.1016/j.bmcl.2014.07.016

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1422361-70-3
2-[(3-{5-[(3,5-dichloropyridin-4-yl)carbamoyl]-2-(difluoromethoxy) phenoxy}propyl)amino]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C

2: potassium carbonate / acetonitrile / 1.5 h / Reflux; Inert atmosphere

3: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 10 °C

4: thionyl chloride / toluene / 1.5 h / 90 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 10 °C / Inert atmosphere

6: potassium carbonate / acetonitrile / 1.5 h / Reflux

7: lithium hydroxide

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2014.07.016