(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester
CAS No.:870255-94-0
Molecular Formula:C₃₂H₄₄N₄O₆
Molecular Weight:580.725
Hs Code.:

(3-{2-[3-(<i>tert</i>-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

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Chemical Property of (3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

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Technology Process of (3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

There total 4 articles about (3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 870255-93-9
C₂₂H₂₀N₄O₂

: 24424-99-5
di-tert-butyl dicarbonate

: 870255-94-0
(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol; at 20 ℃; for 16h;
DOI:10.1002/chem.200500444

Reference yield:

: C₂₀H₁₄NO₅P

: 870255-94-0
(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 3.61 g / aq. K₂CO₃ / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 91 percent / NaBH₄; NiCl₂ / tetrahydrofuran; methanol / 16 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.200500444

Reference yield:

: 1877-72-1
3-Cyanobenzoic acid

: 870255-94-0
(3-{2-[3-(tert-butoxycarbonylamino-methyl)-benzoylamino]-cyclohexylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 3.61 g / aq. K₂CO₃ / CH₂Cl₂ / 16 h / 0 - 20 °C

3: 91 percent / NaBH₄; NiCl₂ / tetrahydrofuran; methanol / 16 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.200500444