BOC-L-homoserine diphenylmethyl ester

Base Information

• Chemical Name: BOC-L-homoserine diphenylmethyl ester
• CAS No.: 123736-84-5
• Molecular Formula: C₂₂H₂₇NO₅
• Molecular Weight: 385.46
• Mol file: 123736-84-5.mol

Synonyms:BOC-L-homoserine diphenylmethyl ester

Chemical Property of BOC-L-homoserine diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-L-homoserine diphenylmethyl ester

There total 5 articles about BOC-L-homoserine diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-Homoserine (1927-25-9,119736-88-8) + 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + diazodiphenylmethane (908093-98-1) → BOC-L-homoserine diphenylmethyl ester (123736-84-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield:

N-tert-butyloxycarbonylasparagine (7536-55-2) → BOC-L-homoserine diphenylmethyl ester (123736-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 1.67 h / 40 - 50 °C

2: 1.) N₂O₄, NaOAc / 1.) AcOH, 5 h, R_.T_., 2.) benzene, 6 h, reflux

3: BH₃ / 1.) THF, 5 h, 0 degC, 2.) MeOH, R_.T_.

With borane; sodium acetate; dinitrogen tetraoxide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)92152-0

Reference yield:

diazodiphenylmethane (908093-98-1) → BOC-L-homoserine diphenylmethyl ester (123736-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 1.67 h / 40 - 50 °C

2: 1.) N₂O₄, NaOAc / 1.) AcOH, 5 h, R_.T_., 2.) benzene, 6 h, reflux

3: BH₃ / 1.) THF, 5 h, 0 degC, 2.) MeOH, R_.T_.

With borane; sodium acetate; dinitrogen tetraoxide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)92152-0

upstream raw materials:

N-BOC-L-aspartic acid-α-benzhydryl ester

N-tert-butyloxycarbonylasparagine

BOC-L-asparagine diphenylmethyl ester

diazodiphenylmethane

Downstream raw materials:

diphenylmethyl L-4-(p-acetylphenoxy)-2-(1-t-butoxyformamido)butyrate

(S)-2-tert-Butoxycarbonylamino-4-(4-oxalyl-phenoxy)-butyric acid benzhydryl ester

benzhydryl DL-2-tert-butoxycarbonylamino-4-phthalimidooxybutyrate

Refernces

• 1、 -. "7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof". . . Retrieved 2008/06/13.