2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

Base Information

Chemical Name:2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide
CAS No.:130097-11-9
Molecular Formula:C₂₄H₃₅NO₅Si
Molecular Weight:445.631
Hs Code.:

Synonyms:2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

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Chemical Property of 2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

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Technology Process of 2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

There total 1 articles about 2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 130097-10-8
2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dihydroxy-phenyl)-2-hydroxy-ethyl]-acetamide

: 130097-11-9
2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: In methanol; diethyl ether; at 25 ℃;
DOI:10.1021/ja00179a061

Reference yield:

: 130097-11-9
2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

: 130097-12-0
2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-chloro-2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 ℃;
DOI:10.1021/ja00179a061

Reference yield:

: 130097-11-9
2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-N-[(R)-2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-acetamide

: 130097-14-2
(2S,5S)-5-(3,4-Dimethoxy-phenyl)-2-(4-hydroxy-benzyl)-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / CH₂Cl₂ / 0 °C

2: i-Pr₂NEt / CH₂Cl₂

3: tetrahydrofuran / -78 °C

4: sodium cyanoborohydride / tetrahydrofuran; ethanol

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 25 °C

With thionyl chloride; tetrabutyl ammonium fluoride; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00179a061