(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Base Information

Chemical Name:(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane
CAS No.:290307-36-7
Molecular Formula:C₂₅H₃₄ClF₂NO₄Si
Molecular Weight:514.085
Hs Code.:

Synonyms:(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Suppliers and Price of (3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

There total 4 articles about (3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 290307-34-5
(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[1-methyl-1-(2-trimethylsilylethoxy)methoxy]ethyl-pyridin-5-yl}methanol

: 290307-36-7
(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Guidance literature:: With pyridine; thionyl chloride; In toluene; at 20 ℃; for 1h;
DOI:10.1021/jm0204542

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 290307-36-7
(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / toluene; hexane / 0.5 h / -78 °C

1.2: 70 percent / toluene; hexane / 0.67 h

2.1: NaH / dimethylformamide / 1.25 h / 0 - 20 °C

2.2: 97 percent / dimethylformamide / 20 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -100 °C

3.2: 100 percent / tetrahydrofuran; hexane / 0.17 h / -100 - -78 °C

4.1: 88 percent / SOCl₂; pyridine / toluene / 1 h / 20 °C

With pyridine; n-butyllithium; thionyl chloride; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 290307-40-3
2-(5-bromopyridin-2-yl)propan-2-ol

: 290307-36-7
(3-cyclopropyloxy-4-difluoromethoxyphenyl)-{2-[2-((2-trimethylsilylethoxy) methoxy)propane-2-yl]5-pyridyl}chloromethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 1.25 h / 0 - 20 °C

1.2: 97 percent / dimethylformamide / 20 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -100 °C

2.2: 100 percent / tetrahydrofuran; hexane / 0.17 h / -100 - -78 °C

3.1: 88 percent / SOCl₂; pyridine / toluene / 1 h / 20 °C

With pyridine; n-butyllithium; thionyl chloride; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0204542