trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

Base Information

Chemical Name:trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate
CAS No.:1315497-63-2
Molecular Formula:C₂₀H₂₇N₅O₂
Molecular Weight:369.467
Hs Code.:

Synonyms:trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

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Chemical Property of trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

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Technology Process of trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

There total 3 articles about trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1315497-62-1
trans-tert-butyl 4-(2-methyl-6-(phenylsulfonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

: 1315497-63-2
trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm300628c

Reference yield:

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1315497-63-2
trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 25 - 80 °C / Inert atmosphere; Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 13 h / 50 °C

3: acetic acid / 0.33 h / Inert atmosphere; Reflux

4: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol;
DOI:10.1021/jm300628c

Reference yield:

: 1315500-19-6
trans-tert-butyl 4-(5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino)cyclohexylcarbamate

: 1315497-63-2
trans-tert-butyl 4-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 0.33 h / Inert atmosphere; Reflux

2: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 25 °C / Inert atmosphere

With water; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm300628c