(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

Base Information

Chemical Name:(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester
CAS No.:122410-29-1
Molecular Formula:C₃₁H₃₅NO₅
Molecular Weight:501.623
Hs Code.:

Synonyms:(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

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Chemical Property of (2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

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Technology Process of (2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

There total 3 articles about (2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105129-13-3
threo-2,4-dibenzylglutaric acid

: 122410-29-1
(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetyl chloride / toluene / 2 h

2: 15percent Et₃N / toluene / 0.25 h / 50 °C

3: toluene / 16 h / Heating

4: N(Et)3, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / Ambient temperature

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride; In dichloromethane; toluene;
DOI:10.1021/jm00132a005

Reference yield:

: 105129-11-1
cis-2,4-dibenzylglutaric anhydride

: 122410-29-1
(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 15percent Et₃N / toluene / 0.25 h / 50 °C

2: toluene / 16 h / Heating

3: N(Et)3, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / Ambient temperature

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm00132a005

Reference yield:

: 105129-09-7
trans-2,4-dibenzylglutaric anhydride

: 122410-29-1
(2R,4R)-2-Benzyl-4-(2-benzyloxycarbonyl-ethylcarbamoyl)-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 16 h / Heating

2: N(Et)3, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / Ambient temperature

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm00132a005