(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

Base Information

Chemical Name:(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid
CAS No.:1239956-90-1
Molecular Formula:C₃₀H₂₈Cl₂F₂N₄O₄S
Molecular Weight:649.546
Hs Code.:

(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

Synonyms:(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

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Chemical Property of (S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

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Technology Process of (S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

There total 4 articles about (S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₄₄Cl₂F₂N₄O₆S

: 1239956-90-1
(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 1239963-44-0
tert-butyl 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylcarbamate

: 1239956-90-1
(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1239956-89-8
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluoroaniline

: 1239956-90-1
(S)-3-amino-4-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylamino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;