[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Base Information

Chemical Name:[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile
CAS No.:920509-57-5
Molecular Formula:C₁₆H₁₅Cl₂N₃O
Molecular Weight:336.221
Hs Code.:

Synonyms:[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

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Chemical Property of [3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Chemical Property:

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Technology Process of [3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

There total 9 articles about [3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920509-56-4
6-(4-(bromomethyl)-2,6-dichlorobenzyl)-4-isopropylpyridazin-3(2H)-one

: 143-33-9,25596-52-5
sodium cyanide

: 920509-57-5
[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: With sulfuric acid; In dimethyl sulfoxide; at 20 - 50 ℃; for 1.5h;

Reference yield:

: 773837-37-9
sodium cyanide

: 920509-56-4
6-(4-(bromomethyl)-2,6-dichlorobenzyl)-4-isopropylpyridazin-3(2H)-one

: 920509-57-5
[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: With sulfuric acid; In dimethyl sulfoxide; at 20 - 50 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm4019299

Reference yield:

: 20098-48-0
3,4,5-trichloronitrobenzen

: 920509-57-5
[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 110 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 60 °C / Inert atmosphere

4.1: acetic acid; hydrogenchloride / water / 24 h / 120 °C

5.1: sulfuric acid; acetic acid; sodium nitrite / water / 1 h / 20 - 60 °C

5.2: 1 h / 100 °C

6.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / acetonitrile / 2.5 h / 20 - 90 °C / 2327.23 Torr / Sealed tube; Inert atmosphere

7.1: diisobutylaluminium hydride / tetrahydrofuran / 24.5 h / 20 - 25 °C / Inert atmosphere

8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

9.1: sulfuric acid / dimethyl sulfoxide / 1.5 h / 20 - 50 °C / Inert atmosphere

With hydrogenchloride; carbon tetrabromide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm4019299