TYRPHOSTIN AG 879

Base Information

• Chemical Name: TYRPHOSTIN AG 879
• CAS No.: 148741-30-4
• Molecular Formula: C18H24 N2 O S
• Molecular Weight: 316.46
• Hs Code.: 2930909090
• Mol file: 148741-30-4.mol

Synonyms:2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (E)-; AG 879;Tyrphostin AG 879

Chemical Property of TYRPHOSTIN AG 879

Chemical Property:

• Vapor Pressure: 4.5E-08mmHg at 25°C
• Boiling Point: 443.8°Cat760mmHg
• Flash Point: 222.2°C
• PSA: 102.13000
• Density: 1.161g/cm³
• LogP: 4.88058
• Storage Temp.: Store at -20°C
• Solubility.: DMSO: at 26 mg/mlsoluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

AG 879 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: AG-879 (148741-30-4) inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 μM). No inhibition of EGF, or PDGF receptor phosphorylation is observed at typical working concentrations.
• Uses: Tyrphostin AG 879 is a dual EGFR/HER2 inhibitor that was administered together with androgen withdrawal therapy and was shown to sensitize prostate cancer cells to apoptosis.