N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

Base Information

Chemical Name:N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide
CAS No.:1450819-70-1
Molecular Formula:C₃₃H₃₁ClF₄N₆O₄
Molecular Weight:687.094
Hs Code.:

Synonyms:N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

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Chemical Property of N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

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Technology Process of N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

There total 5 articles about N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89402-29-9
2-bromo-3-fluoro-5-(trifluoromethyl)-pyridine

: 1441142-56-8
tert-butyl 4-[[3-[[4-chloro-2-(1H-pyrazole-4-carbonyl)phenyl]carbamoyl]phenyl]methyl]piperazine-1-carboxylate

: 1450819-70-1
N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

Guidance literature:: With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; In isopropyl alcohol; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 152493-32-8
(5-chloro-2-nitro-phenyl)-(1-tritylpyrazol-4-yl)methanone

: 1450819-70-1
N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: iron; acetic acid / ethanol; water / 1 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

3: trifluoroacetic acid / water / 2 h / 60 °C

4: potassium carbonate / acetonitrile / 60 °C

5: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / isopropyl alcohol / 1 h / 120 °C / Microwave irradiation

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1441142-15-9
3-(chloromethyl)-N-[4-chloro-2-(1-tritylpyrazole-4-carbonyl)phenyl]benzamide

: 1450819-70-1
N-[4-chloro-2-[1-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]pyrazole-4-carbonyl]phenyl]-3-(piperazin-1-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / water / 2 h / 60 °C

2: potassium carbonate / acetonitrile / 60 °C

3: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / isopropyl alcohol / 1 h / 120 °C / Microwave irradiation

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; trifluoroacetic acid; In water; isopropyl alcohol; acetonitrile;