Technology Process of (+/-)-1-phenyl-2-tosyl-3-vinyl-1,2,3,4-tetrahydroisoquinoline
There total 7 articles about (+/-)-1-phenyl-2-tosyl-3-vinyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2E)-4-(2-((tosylimino)methyl)phenyl)but-2-enyl acetate; phenylboronic acid;
With
potassium phosphate; C44H44Cl2O2P2Pd2; barium(II) oxide;
In
toluene;
at 80 ℃;
for 1.5h;
Inert atmosphere;
With
dichloro bis(acetonitrile) palladium(II); trifuran-2-yl-phosphane;
In
dichloromethane; toluene;
at 80 ℃;
for 1h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201008160
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 - -65 °C / Inert atmosphere
1.2: 1 h / 20 °C
2.1: dmap; triethylamine / dichloromethane / 1 h / Inert atmosphere
3.1: titanium tetrachloride; triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere
4.1: potassium phosphate; C44H44Cl2O2P2Pd2; barium(II) oxide / toluene / 1.5 h / 80 °C / Inert atmosphere
4.2: 1 h / 80 °C / Inert atmosphere
With
dmap; potassium phosphate; C44H44Cl2O2P2Pd2; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; barium(II) oxide;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.201008160
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride; triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere
2.1: potassium phosphate; C44H44Cl2O2P2Pd2; barium(II) oxide / toluene / 1.5 h / 80 °C / Inert atmosphere
2.2: 1 h / 80 °C / Inert atmosphere
With
potassium phosphate; C44H44Cl2O2P2Pd2; titanium tetrachloride; triethylamine; barium(II) oxide;
In
dichloromethane; toluene;
DOI:10.1002/anie.201008160
