2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

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Chemical Name:2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane
CAS No.:1417392-19-8
Molecular Formula:C₂₁H₂₅FN₄O₃S
Molecular Weight:432.519
Hs Code.:

Synonyms:2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

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Chemical Property of 2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

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Technology Process of 2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

There total 6 articles about 2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1417392-18-7
4-chloro-6-(2-fluoro-4-(methylsulfonyl)phenoxy)-5-methylpyrimidine

: 39122-99-1
C₉H₁₆N₂

: 1417392-19-8
2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

Guidance literature:: With caesium carbonate; In acetonitrile; at 180 ℃; for 1h; Irradiation;
DOI:10.1021/jm301626p

Reference yield:

: 49738-67-2
C₁₆H₂₃BrN₂

: 1417392-19-8
2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 0.5 h / 65 - 70 °C

2.1: N-chloro-succinimide / diethyl ether / 0.22 h / 23 °C / Inert atmosphere

2.2: 0.83 h / Inert atmosphere; Irradiation

3.1: hydrogen; palladium on activated charcoal / methanol / 4 h / 60 °C

4.1: caesium carbonate / acetonitrile / 1 h / 180 °C / Irradiation

With N-chloro-succinimide; sulfuric acid; palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; diethyl ether; water; acetonitrile; 2.1: |Hofmann-Loeffler-Freytag Synthesis / 2.2: |Hofmann-Loeffler-Freytag Synthesis;
DOI:10.1021/jm301626p

Reference yield:

: 39122-97-9
2-benzyl-6-methyl-2,6-diazatricyclo[3.3.1.1^3,7]decane

: 1417392-19-8
2-{6-[2-fluoro-4-(methylsulfonyl)phenoxy]-5-methylpyrimidin-4-yl}-6-methyl-2,6-diazatricyclo[3.3.1.1～3,7～]decane

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol / 4 h / 60 °C

2: caesium carbonate / acetonitrile / 1 h / 180 °C / Irradiation

With palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; acetonitrile;
DOI:10.1021/jm301626p