2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

• Chemical Name: 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
• CAS No.: 444667-38-3
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.452
• Mol file: 444667-38-3.mol

Synonyms:2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property of 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 1 articles about 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1R,3R,4S)-8-phenylmenthyl 2-methylacetoacetate (192199-24-9) → 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (444667-38-3)

Guidance literature:

(1R,3R,4S)-8-phenylmenthyl 2-methylacetoacetate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

With Phenylselenyl chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

In dichloromethane; at 0 ℃; for 3h; Further stages.;

DOI:10.1021/jo025670x

Reference yield: 79.0%

O-4-nitrophenylsulfonyl-tert-butylhydroxamic acid + 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (444667-38-3) → 2-Acetyl-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester

Guidance literature:

With calcium oxide; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo025670x

Reference yield: 78.0%

ethyl N-{[(4-nitrobenzene)sulfonyl]oxy}carbamate (2955-74-0) + 2-Methylene-3-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (444667-38-3) → 2-Acetyl-aziridine-1,2-dicarboxylic acid 1-ethyl ester 2-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester

Guidance literature:

With calcium oxide; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo025670x

upstream raw materials:

(1R,3R,4S)-8-phenylmenthyl 2-methylacetoacetate