Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester
CAS No.:182176-31-4
Molecular Formula:C₃₄H₃₅N₃O₆
Molecular Weight:581.668
Hs Code.:

Synonyms:Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

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Chemical Property of Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

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Technology Process of Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

There total 4 articles about Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17186-53-7,92698-80-1
L-phenylalanine cyclohexylamide

: 182176-31-4
Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Et(i-Pr)2N / various solvent(s) / 32 h / 80 °C / in NMP

2: 1.) CF₃COOH 2.) SOCl₂ / 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 18 h

3: 1.) 2 N HCl 2.) Et(i-Pr)2N / 1.) dioxane, 0 deg C, 3 h; 2.) CH₂Cl₂, 0 deg C, 30 min.

With hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In various solvent(s);
DOI:10.1002/hlca.19960790508

Reference yield:

: (4-Iodomethyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert-butyl ester

: 182176-31-4
Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Et(i-Pr)2N / various solvent(s) / 32 h / 80 °C / in NMP

2: 1.) CF₃COOH 2.) SOCl₂ / 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 18 h

3: 1.) 2 N HCl 2.) Et(i-Pr)2N / 1.) dioxane, 0 deg C, 3 h; 2.) CH₂Cl₂, 0 deg C, 30 min.

With hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In various solvent(s);
DOI:10.1002/hlca.19960790508

Reference yield:

: 182176-20-1
[(R)-4-((S)-1-Cyclohexylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-acetic acid tert-butyl ester

: 182176-31-4
Benzoic acid (R)-3-benzoylamino-1-((S)-1-cyclohexylcarbamoyl-2-phenyl-ethyl)-2,5-dioxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CF₃COOH 2.) SOCl₂ / 1.) CH₂Cl₂, r.t., 5 h 2.) CH₂Cl₂, r.t., 18 h

2: 1.) 2 N HCl 2.) Et(i-Pr)2N / 1.) dioxane, 0 deg C, 3 h; 2.) CH₂Cl₂, 0 deg C, 30 min.

With hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
DOI:10.1002/hlca.19960790508